3/9/2023 0 Comments Stem cell treatment alsWe hope to do two patients a month, one at each institution, for a total of 36 patients. We’ve submitted Phase II of our trial to the Food and Drug Administration (FDA), in which patients will be given injections at both Emory University and the U of M. The idea behind injecting the cervical cord is to be able to preserve the large nerve cells that control breathing, as most patients with ALS eventually die from the inability to breathe. The first 12 operations were in the lower part of the spinal cord and the last six operations were in the upper part-the cervical cord. We transplanted patients in groups of three and each group had better neurologic function after the transplant than before it. With Phase I, we’ve shown the safety of the procedure, which was called a risk escalation trial. and Chet Cooper spent an afternoon learning more about Feldman and her work.Ĭhristoph J.B.: As I understand it, Phase I of this trial was the first of its kind in the world.ĭr. Given the promising results of Phase I, it seems there is exciting potential in harnessing stem cells to slow down or completely arrest the progression of ALS and other enigmatic diseases. And each patient received either 5 or 10 injections.Īlthough Phase I was to simply prove the procedure was safe, a subgroup of patients experienced signs that their ALS progression had been interrupted as a result of receiving stem cells. In the first of a three-phase trial, 100,000 stem cells were transplanted into each patient via a spinal cord injection. The latter causes progressive weakness, muscle atrophy and respiratory difficulties.Īs a neurology professor at the University of Michigan (U of M), Feldman helped pioneer the initial clinical trial of intraspinal stem cell transplantation in patients with ALS. Eva Feldman, MD and PhD, works closely with her research team to seek cures for some of the world’s most devastating diseases, including Alzheimer’s, diabetic neuropathy and amyotrophic lateral sclerosis (ALS), which is often called Lou Gehrig’s disease.
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